Table 2. Incidence and Overall Survival of Patients With HPD According to the Different Definitions.
| Variable | Definition A | Definition B | Definition C | Definition D | Definition E |
|---|---|---|---|---|---|
| Incidence, No./total No. (%) | 52/406 (12.8) | 22/406 (5.4) | 75/406 (18.5) | 25/406 (6.2) | 56/406 (13.8) |
| Median OS (95% CI), mo | |||||
| HPD group | 5.1 (3.3-9.4) | 3.4 (1.9-8.4) | 6.0 (3.7-9.4) | 5.1 (3.2-10.3) | 4.0 (2.9-7.5) |
| PD non-HPD group | 6.3 (5.0-7.5) | 6.4 (5.6-8.4) | 6.2 (5.0-7.5) | 6.2 (5.3-7.5) | 6.4 (5.5-8.4) |
| P valuea | .45 | <.001 | .62 | .59 | .14 |
Abbreviations: HPD, hyperprogressive disease; OS, overall survival; PD, progressive disease. For HPD definitions A through E, see Table 1.
a
Log-rank tests were computed to test the significance of this distinction.