Table 3. Influence of the Definition on the HPD Subset Constitution.
| Definition | Jaccard index value, No. (%)a | ||||
|---|---|---|---|---|---|
| Definition A (n = 52) | Definition B (n = 22) | Definition C (n = 75) | Definition D (n = 25) | Definition E (n = 56) | |
| A | NA | NA | NA | NA | NA |
| B | 19 (34.5) | NA | NA | NA | NA |
| C | 52 (69.3) | 21 (27.6) | NA | NA | NA |
| D | 25 (48.1) | 22 (67.9) | 25 (33.3) | NA | NA |
| E | 44 (68.8) | 23 (34.8) | 49 (59.8) | 24 (47.4) | NA |
Abbreviations: HPD, hyperprogressive disease; NA, not applicable. For HPD definitions A through E, see Table 1.
a
The Jaccard index value corresponds to the proportion of patients with HPD in common among all patients assessed as having HPD by one definition or the other. For instance, definitions A and E assessed 44 patients with HPD in common but another 20 patients were assessed as having HPD by only 1 of the 2 definitions (52 – 44 = 8 in A and 56 – 44 = 12 in E), leading to a similarity index of 44 of 64 = 68.8%.