Table 3. Multivariable Analysis Including the H-Index as an Independent Variable Associated With Overall Survival.
| Variable | HR (95% CI) | |
|---|---|---|
| Univariable analysis | Multivariable analysis | |
| Age, y | ||
| ≤60 | 1 [Reference] | 1 [Reference] |
| >60 | 1.955 (1.631-2.343) | 1.807 (1.481-2.203) |
| Tobacco use | ||
| Never | 1 [Reference] | 1 [Reference] |
| Ever | 1.305 (1.091-1.561) | 1.033 (0.850-1.255) |
| WUHNCIa | ||
| 0 | 1 [Reference] | 1 [Reference] |
| ≥1 | 1.624 (1.363-1.936) | 1.273 (1.050-1.544) |
| Lymphovascular invasion | ||
| Absent | 1 [Reference] | 1 [Reference] |
| Present | 2.100 (1.690-2.611) | 1.181 (0.922-1.512) |
| Perineural invasion | ||
| Absent | 1 [Reference] | 1 [Reference] |
| Present | 2.209 (1.855-2.630) | 1.374 (1.111-1.699) |
| Margin status | ||
| Negative | 1 [Reference] | 1 [Reference] |
| Close | 1.544 (1.256-1.900) | 1.262 (1.000-1.591) |
| Positive | 3.051 (2.343-3.973) | 1.949 (1.426-2.663) |
| Histologic grade | ||
| Differentiated | ||
| Well | 1 [Reference] | 1 [Reference] |
| Moderately | 1.548 (1.204-1.990) | 1.084 (0.808-1.454) |
| Poorly | 2.179 (1.619-2.931) | 1.035 (0.721-1.486) |
| pTb | ||
| pT1 | 1 [Reference] | 1 [Reference] |
| pT2 | 1.657 (1.274-2.153) | 1.197 (0.897-1.596) |
| pT3 | 2.624 (2.024-3.401) | 1.309 (0.958-1.789) |
| pT4 | 4.136 (3.239-5.281) | 1.582 (1.161-2.157) |
| pNb | ||
| pN0 | 1 [Reference] | 1 [Reference] |
| pN1 | 1.487 (1.109-1.993) | 1.264 (0.921-1.736) |
| pN2 | 2.200 (1.699-2.850) | 1.594 (1.200-2.118) |
| pN3 | 5.681 (4.565-7.069) | 2.966 (2.255-3.901) |
| H-index | ||
| ≤1.4 | 1 [Reference] | 1 [Reference] |
| 1.5-3.5 | 1.474 (1.208-1.798) | 1.262 (1.016-1.567) |
| ≥3.6 | 3.221 (2.557-4.058) | 1.988 (1.521-2.598) |