Table 5.
The candidate genomic regions and genes identified to be under selection by the XP-EHH approach for the comparison between the short fat-tailed (Yabuyi sheep) and log fat-tailed (Karakul sheep) breeds.
| OAR | Gene Position (bp) | Gene Name | Function |
|---|---|---|---|
| 10 | 35,583,842–35,609,414 | FGF9 | Early gonadal development/testosterone biosynthesis |
| 10 | 35,786,789–35,798,732 | SKA3 | Disease resistance |
| 10 | 35,862,425–35,885,746 | LATS2 | Pubertal development of male reproductive tract and spermatogenesis |
| 10 | 36,045,326–36,103,818 | IFT88 | Reproduction |
| 11 | 15,474,422–15,476,403 | CCL11 | Disease resistance |
| 11 | 36,435,040–36,455,430 | FAM117A | Regulation of ovulation rate |
| 11 | 37,337,231–37,338,988 | HOXB13 | Tail formation |
| 11 | 40,552,263–40,557,934 | KRT27 | Wool follicle and fiber morphology |
| 11 | 46,503,733–46,5282,30 | MRC2 | Immunity |
| 14 | 14,231,363–14,232,541 | MC1R | Black coat color and pigmentation |
| 2 | 72,847,41–75,096,31 | PAPPA | Reproduction (follicle development) |
| 2 | 12,325,968–12,488,187 | LPAR1 | Reproduction (embryo development) |
| 2 | 14,235,503,1–14,244,934,8 | SCN1A | Disease resistance (epilepsy) |
| 2 | 24,675,580,7–24,686,431,8 | PAX7 | Regulation of myogenesis/proliferation |
| 24 | 34,631,867–349,509,62 | CUX1 | Reproduction (Fetal development) |
| 3 | 94,005,022–94,024,647 | CYP26B1 | Regulation of spermatogenesis |
| 3 | 19,093,521,6–19,139,918,6 | SOX5 | Ear developmental processes |
| 3 | 19,337,134,2–193,429,711 | GYS2 | Hepatocyte growth factor |
| 3 | 19,343,685,7–19,344,439,8 | SPX | Antibody response |
| 3 | 20,164,430,6–20,166,437,1 | GSG1 | Fetal development |
| 3 | 20,729,131,1–20,733,999,1 | C1R | Immunity |
| 3 | 20,735,340,8–20,736,655,7 | C1S | Immunity |
| 3 | 20,744,522,8–20,744,919,3 | PHB2 | Embryo development |
| 3 | 20,745,499,6–20,746,386,0 | PTPN6 | Metabolism |
| 3 | 20,758,319,4–20,760,861,0 | CD4 | Immunity (enhances antibody responses) |
| 3 | 20,792,799,7–20,793,488,5 | LTBR | Immune response |
| 3 | 20,798,068,7–20,798,484,4 | TNFRSF1A | Disease resistance |
| 3 | 20,806,906,2–20,808,248,0 | CD9 | Various cellular processes (immune, growth, reproduction). |
| 3 | 20,816,481,5–20,828,841,8 | VWF | Disease resistance |
| 3 | 20,830,234,2–20,864,109,0 | ANO2 | Antibody |
| 9 | 13,460,501–13,464,151 | VPS28 | Growth factor |
| 9 | 14,648,230–14,719,519 | ADGRB1 | Resistance to diarrhea |
| 9 | 15,738,938–15,903,858 | PTK2 | Reproduction |