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. 2020 May 9;9(5):1178. doi: 10.3390/cells9051178

Table 1.

Experimental protocols of house dust mite-induced murine asthma models.

Reference Mouse Strain Protocol Result
[75] BALB/c graphic file with name cells-09-01178-i001.jpg
Increased ILC2 in lung and BALF

Lung ILC2 produced IL-5, IL-13, IL-4

IL-5 + and IL-13 + cells accounted for a significant proportion of ILC2 in lung and BAL

The contribution of ILC2 cells to the total population of IL-5 + and IL-13 + cells in the BAL was in the same range as seen for Th2 cells.
[76] C57BL/6 graphic file with name cells-09-01178-i002.jpg No elevation of IL-5, IL-13 and IL-33 in BAL
[77] C57BL/6 graphic file with name cells-09-01178-i003.jpg Elevation of eosinophils in BALF

Elevation of lung ILC2, serum IgE and transcription level of IL-4 or IL-5 from lung RNA

Leukocyte infiltration into the lung tissue, particular in the peribronchiolar and perivascular space.

i.t: intratracheal, i.n: intranasal, HDM; house dust mite, ILC2: group 2 innate lymphoid cell, IL: interleukin, BALF; bronchoalveolar lavage fluid, Th2:, T helper 2, RNA: ribonucleic acid.