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. 2020 May 19;9(5):1250. doi: 10.3390/cells9051250

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Platelet-rich plasma (PRP) as a source of platelet-derived biomaterials for ED therapy. Blood-derived PRP is highly rich in growth factors such as VEGF, IGF-1, FGF, PDGF, and TGF-β and plays a critical role in the proliferation and differentiation of MSCs, angiogenesis, blood flow regulation, neuro protection, nerve regeneration, axonal myelination, ECM, and collagen synthesis, resulting in an improved index of erectile function (IIEF-5). IGF: insulin-like growth factor, VEGF: vascular endothelial growth factor, FGF: fibroblast growth factor, PDGF: platelet-derived growth factor, TGF-β: transforming growth factor beta.