Table 2.
Comparison of the S gene sequence variants of the MERS-CoV isolates from the patients in Saudi Arabia, 2015–2017, and reference strains.
| S1 Subunit | S2 Subunit | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NTD | RBD | HR | ||||||||||||||
| MERS-CoV Strains | 32 | 95 | 126 | 200 | 222 | 228 | 473 | 556 | 588 | 700 | 710 | 745 | 848 | 1020 | 1224 | 1267 |
| JX869059-England-2012/06/13 * | E | T | S | S | N | F | F | A | L | R | P | L | N | Q | G | L |
| MN735680-Saudi Arabia-14-2016 | R | |||||||||||||||
| MN735679-Saudi Arabia-03-2015 | A | R | ||||||||||||||
| MN735681-Saudi Arabia-81-2017 | R | |||||||||||||||
| MN735682-Saudi Arabia-109-2017 | D | R | ||||||||||||||
| MK858156-Saudi Arabia-19-2016 | R | |||||||||||||||
| MK858157-Saudi Arabia-24-2016 | L | R | ||||||||||||||
| MK858158-Saudi Arabia-26-2016 | R | |||||||||||||||
| MK858159-Saudi Arabia-30-2016 | Y | R | ||||||||||||||
| MK858160-Saudi Arabia-37-2017 | A | L | F | R | ||||||||||||
| MK858161-Saudi Arabia-40-2017 | A | L | F | R | ||||||||||||
| MK858162-Saudi Arabia-41-2017 | A | L | F | R | ||||||||||||
| MK858163-Saudi Arabia-42-2017 | R | |||||||||||||||
| MK858164-Saudi Arabia-44-2017 | R | S | ||||||||||||||
| KT806006-Saudi Arabia-2015 * | Y | V | R | S | ||||||||||||
| KT805971-Saudi Arabia-2015 * | A | R | ||||||||||||||
| MG011342-Saudi Arabia-2016 * | I | I | H | R | ||||||||||||
| MG912606-Saudi Arabia-2017 * | A | L | S | F | R | |||||||||||
* Amino acid changes in the study sequences compared to the prototype sequences are shaded in gray. Amino acid abbreviations: Glutamic acid (E); Alanine (A); Threonine (T); Isoleucine (I); Serine (S); Tyrosine (Y); Asparagine (N); Phenylalanine (F); Leucine (L); Arginine (R); Proline (P); Aspartic acid (D); Glutamine (Q); Glycine (G).