Table 2.
Wnt components have roles in various chronic kidney diseases (CKDs).
| Wnt Component | Disease | Model | References |
|---|---|---|---|
| WNT1 | FSGS | Human | [42] |
| WNT4 | PKD, Membranous Nephropathy | Human, mouse | [43,44] |
| WNT5A | ARPKD, ESRD | Human | [45,46,47] |
| WNT9B | PKD | Mouse | [48,49] |
| WNT11 | PKD | Mouse | [50] |
| LRP5 | ADPKD | Human, cell line (HEK293) | [51] |
| LRP6 | PKD | Mouse | [52] |
| β-catenin | ADPKD, IgAN, FSGS | Human, mouse, cell line (renal collecting duct cell line) | [42,53,54,55] |
| NPHP2/Inversin | ADPKD, IgAN, NPHP | Human | [53] |
| VANGL2 | ARPKD | Human | [47] |
| CELSR2 | JS | Human | [56] |
| SCRIBBLE | ARPKD | Human | [47] |