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. 2020 May 1;9(5):1123. doi: 10.3390/cells9051123

Figure 4.

Figure 4

The effect of CDDO-Me on p38 MAPK phosphorylation in microglia following SE. SE increases p38 MAPK phosphorylation in the FPC without altering its expression level, which is ameliorated by CDDO-Me. p38 MAPK phosphorylation is increased in resident IB4 microglia following SE, which is abrogated by CDDO-Me. (A) Representative Western blot image for p38 MAPK and p-p38 MAPK. (B) Quantification of the effect of CDDO-Me on p38 MAPK phosphorylation based on Western blot data. Error bars indicate SEM (*,# p < 0.05 vs. control and vehicle, respectively; n = 7, respectively). (C) Representative images for p38 MAPK phosphorylation in IB4 microglia. (D and E) Quantification of the effect of CDDO-Me on the number of p-p38 MAPK positive cells (D) and p-p38 MAPK signals (E) following SE. Error bars indicate SEM (* p < 0.05 vs. vehicle; n = 7, respectively).