Table 1.

Eight statements about uncultured, autologous, fresh, unmodified, adipose derived regenerative cells (UA-ADRCs) and their application in regenerative medicine, reflecting the current state of knowledge in the literature.

Why and How Regenerative Cells Should be Isolated from Adipose Tissue rather than from Other Tissues, and How these Cells are Characterized
1.	ADRCs are neither ‘fat stem cells’ nor could they exclusively be isolated from adipose tissue, as ADRCs contain the same adult stem cells that are ubiquitously present in the walls of small blood vessels that are capable of differentiating into somatic cells of the three germ layers.
2.	The specific isolation procedure used has a significant impact on the number and viability of the cells and hence on safety and efficacy of UA-ADRCs.
3.	There is no need to further separate adipose-derived stem cells (ASCs) from ADRCs if the latter were adequately isolated from adipose tissue.
4.	The minimal definitions of stem cells established by the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT) are somewhat inadequate and misleading and should be amended.
The Rationale and Advantages of Using UA-ADRCs in Regenerative Medicine
5.	Published peer reviewed clinical research demonstrates tissue regeneration with UA-ADRCs to be safe and effective.
How UA-ADRCs Exert Their Function in Tissue Regeneration
6.	UA-ADRCs have the intrinsic capacity to adequately regenerate tissue without need for more than minimal manipulation, stimulation and/or (genetic) reprogramming of the cells.
7.	Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use.
8.	A certain challenge in research with UA-ADRCS lays in the fact that labeling the cells would render them modified, and unmodified cells can only be indirectly identified after transplantation in a target tissue.