Figure 2.
Effect of ONX 0914 on the manifestation of acute viral myocarditis in NMRI mice. (A) Mice were infected with 5 × 105 pfu CVB3 strain 31-1-93 (day 0). From day 3, mice received either ONX 0914 or vehicle daily until day 8. (B) Body weight was monitored as indicated. (C) Viral titers in hearts of both vehicle and ONX 0914-treated mice were determined by plaque assay. (D) Mice were then sacrificed, and heart tissue was analyzed microscopically for inflammation and fibrosis. (E) Histological images of two representative animals per group are shown. Data are summarized as mean ± SEM. Body weight was analyzed using two-way ANOVA, all remaining data were analyzed by unpaired t-tests.