Table 1.
Analysis of cardiac function in NMRI mice during chronic myocarditis.
| Collumn Name | Vehicle | ONX 0914 | ||
|---|---|---|---|---|
| Baseline | Day 28 | Baseline | Day 28 | |
| Heart rate (bpm) | 417 ± 18 | 440 ± 18 | 440 ± 18 | 426 ± 14 |
| Trace EF (%) | 46 ± 2.5 | 48.1 ± 2.9 | 43.6 ± 2.6 | 42.7 ± 2.0 |
| Cardiac output (mL/min) | 13.6 ± 1.0 | 14.6 ± 1.0 | 14.3 ± 1.1 | 14.0 ± 0.8 |
| Stroke volume (µL) | 32.4 ± 1.8 | 32.7 ± 1.5 | 32.0 ± 1.9 | 33.0 ± 1.8 |
| Vol d (µL) | 70.5 ± 1.7 | 70.0 ± 3.1 | 74.2 ± 3 | 77.0 ± 2.2 |
| Vol s (µL) | 38.1 ± 1.9 | 37.3 ± 3.0 | 42.2 ± 2.9 | 44.2 ± 2.0 |
| LVID-d (mm) | 4.3 ± 0.1 | 4.3 ± 0.1 | 4.3 ± 0.1 | 4.5 ± 0.1 |
| LVID-s (mm) | 3.2 ± 0.1 | 3.1 ± 0.1 | 3.2 ± 0.1 | 3.5 ± 0.1 |
Echocardiography was performed prior to infection (day 0) and on day 28 post-infection. After infection, mice received ONX 0914, starting on day 3 (n = 20 ONX 0914). Age- and gender-matched vehicle-treated mice served as controls (n = 20 vehicle). Data shown are mean values ± SEM and were analyzed using repeated measurements two-way ANOVA, yielding no significant changes. EF = ejection fraction; bpm = beats per minute; Vol d/s = end-diastolic/-systolic left ventricular volume; LVID-d/s = left ventricular diameter at diastole/systole.