Table 2.
Analysis of cardiac function in NMRI mice during acute myocarditis.
| Vehicle | ONX 0914 | |||
|---|---|---|---|---|
| Baseline | Day 8 | Baseline | Day 8 | |
| Heart rate (bpm) | 427 ± 16 | 393 ± 16 | 500 ± 13 * | 405 ± 23 § |
| Trace EF (%) | 50.7 ± 1.7 | 48.4 ± 2.6 | 57.4 ± 2.3 | 49.1 ± 3.2 § |
| Cardiac output (mL/min) | 14.4 ± 1.2 | 10.0 ± 0.9 § | 18.6 ± 1.2 * | 12.1 ± 1.3 § |
| Stroke volume (µL) | 33.6 ± 2.1 | 25.2 ± 1.4 § | 37.3 ± 2.4 | 29.6 ± 2.3 § |
| Vol d (µL) | 66.5 ± 4.0 | 52.8 ± 3.0 § | 65.5 ± 4.0 | 60.3 ± 2.6 |
| Vol s (µL) | 33.0 ± 2.4 | 27.6 ± 2.6 | 28.1 ± 2.5 | 30.7 ± 2.3 |
| LVID-d (mm) | 4.2 ± 0.1 | 4.0 ± 0.1 | 4.2 ± 0.1 | 4.2 ± 0.1 |
| LVID-s (mm) | 3.1 ± 0.1 | 3.0 ± 0.1 | 2.9 ± 0.1 | 3.2 ± 0.1 |
ONX 0914 (10 mg/kg BW) was initiated in naive NMRI mice one day prior to infection. Echocardiography was performed at baseline (day 0) and on day 8 post-infection. Age- and gender-matched vehicle-treated littermates served as controls (n = 10 vehicle and n = 10 ONX 0914). Data shown are mean values ± SEM and were analyzed using repeated measurements two-way ANOVA, followed by Sidak’s multiple comparison test. § indicates significant differences in the respective treatment group at day 8 compared to this groups’ baseline measurement. * indicates significant differences regarding ONX 0914 treatment prior to infection. EF = ejection fraction; bpm = beats per minute; Vol d/s = end-diastolic/-systolic left ventricular volume; LVID-d/s = left ventricular inner dimension at diastole/systole.