Table 2.
Prioritization result for top hub-genes, harboring functional candidate variants, from differentially co-expressed modules between high-fertile (HF) and sub-fertile (SF) animals.
| Gene ID | Mapped Candidate Modules | Top Hub-Gene Candidate Modules | Overall Adjusted p-Value (FDR 5%) |
|---|---|---|---|
| ENSBTAG00000046047 | Cyan HF | Cyan HF | NA * |
| PWP2 | Cyan HF, Lightgreen SF | Cyan HF, Lightgreen SF | 0.112 |
| DACT2 | Darkgreen HF | Darkgreen HF | 0.028 ** |
| MIA3 | Green HF | Green HF | 0.032 ** |
| COLGALT2 | Green HF | Green HF | 0.109 |
| SKA2 | Grey60 HF | Grey60 HF | 0.05 |
| MAPKAP1 | Grey60 HF | Grey60 HF | 0.018 ** |
| PPP1R12B | Lightgreen HF | Lightgreen HF | 0.026 ** |
| SLC25A15 | Lightgreen HF | Lightgreen HF | 0.09 |
| EEF1AKMT1 | Lightgreen HF | Lightgreen HF | 0.1 |
| PARP4 | Lightgreen HF | Lightgreen HF | 0.052 |
| FMO2 | Purple HF | Purple HF | 0.061 |
| MDM4 | Red HF | Red HF | 0.018 ** |
| RABIF | Red HF | Red HF | 0.109 |
| CCDC181 | Saddlebrown HF | Saddlebrown HF | 0.085 |
| F2RL2 | Saddlebrown HF | Saddlebrown HF | 0.028 ** |
| IQCG | Tan HF | Tan HF | 0.022 ** |
| HACL1 | Tan HF | Tan HF | 0.09 |
| PIGR | Turquoise HF | Turquoise HF | 0.026 ** |
| ARHGEF16 | Turquoise HF | Turquoise HF | 0.028 ** |
| NRDE2 | Lightgreen SF | Lightgreen SF | 0.278 |
| IFT80 | Turquoise HF, Paleturquoise SF | Paleturquoise SF | 0.028 ** |
* NA = not applicable as it was not possible to obtain a gene symbol for this transcript; ** significant prioritization at a significance level of 0.05 after false discovery rate (FDR) correction.