Table 3.

Prioritization result for the significant upstream regulators, harboring functional candidate variants, from differentially co-expressed modules between high-fertile (HF) and sub-fertile (SF) animals.

Gene ID	Mapped Candidate Modules	Regulated Module	Target Genes	Adjusted p-Value (FDR 5%) Upstream Regulation	Overall Adjusted p-Value (FDR 5%) for Prioritization
EGFR	Darkgreen HF	Turquoise HF	BIRC5, CCNA2, CXCL5, E2F1, EXOSC5, FKBP11, FOXP3, GFAP, HMGB3, HNRNPA1, IGBP1, ITGA6, MYBL2, PDK1, PROM1, PSEN1, RANBP1, SEMA7A, SKP2, TUBA4A, TUBB4A, VEGFA	0.003	0.002 *
EGFR	Darkgreen HF	Cyan HF	CCT5, EIF5A, EPS15, GADD45A, NUTF2, ODC1, PPIA, PSMB5, STAT3, TPST1	0.003	0.002 *
ETV5	-	Turquoise HF	AQP5, CHSY1, KRT19, KRT7, MYB, RAB27A, TJP3, VEGFA	0.016	0.009 *
KLF4	-	Turquoise HF	CCND2, CRABP2, DUSP5, E2F1, HES1, KRT14, KRT19, KRT7, MSX2, PAX2, PROM1, VEGFA, WNT5A	0.032	0.006 *
TCHP	-	Turquoise HF	VEGFA	0.039	0.028 *
COX7A2	-	Turquoise HF	STAR	0.039	0.147
PIK3C2A	-	Turquoise HF	VEGFA	0.039	0.009 *
ARID4A	-	Turquoise HF	E2F1, FOXP3	0.039	0.046 *
ARID4A	-	Saddlebrown HF	HOXB6	0.039	0.046 *
ARID4A	-	Grey60 HF	HOXB3, HOXB5	0.039	0.046 *
CUX1	Cyan HF	Turquoise HF	CCNA2, LTF, RAB36, WNT5A	0.047	0.006 *
PGR	Turquoise HF	Turquoise HF	AK3, HES1, HPGD, ITGA6, MSX2, NPC1, PDGFA, PGR, PPM1H, PRRX1, TAT	0.047	0.006 *
PGR	Turquoise HF	Cyan HF	LIG1, MAP2K3, STAT3, TSC22D3, UCK2, URB2	0.047	0.006 *
IPO9	-	Turquoise HF	PTK2B	0.047	0.09
DLG1	Red HF	Tan HF	KCNJ2	0.045	0.006 *
AGER	-	Saddlebrown HF	CCL4, TJP1	0.046	0.006 *
SORT1	-	Saddlebrown HF	UBE2I	0.047	0.009 *
HNRNPAB	Purple HF	Saddlebrown HF	TJP1	0.047	0.031 *
TBX6	Tan HF	Red HF	HES7	0.049	0.024 *
HSF1	-	Purple HF	CCT4, FKBP4, HSF2, HSP90AA1, HSPA8, HSPH1, KNTC1, RELA, SPHK2, STIP1	0.003	0.009 *
HSF1	-	Darkgreen HF	CSRP2, EFEMP1, INHBB, RPL22	0.003	0.009 *
NUB1	-	Red HF	NEDD8	0.046	0.088
DPH5	-	Red HF	NFKBIA, RELA	0.046	0.077
LEPR	Darkgreen HF	Lightgreen HF	ANGPTL4, CDK2, MMP7, PLP1, SOCS2	0.044	0.006 *
DYSF	Tan HF	Lightgreen HF	CD48, DNAJB1, FCGR2B	0.044	0.012 *
API5	Purple HF	Lightgreen HF	CDK2	0.044	0.077
BCKDK	-	Lightgreen HF	PLP1	0.047	0.041 *
DUSP16	Turquoise HF	Lightgreen HF	VCAM1	0.047	0.014 *
CHFR	Cyan HF	Grey60 HF	PLK1	0.046	0.032 *
PROM1	Turquoise HF	Green HF	DSG2	0.044	0.006 *
ERN2	Grey60 HF	Green HF	XBP1	0.046	0.031 *
UTP3	-	Darkgreen HF	IGLL1/IGLL5	0.043	0.112
RDH10	-	Darkgreen HF	RDH5	0.045	0.032 *

* Significant prioritization at a significance level of 0.05 after false discovery rate correction.