Table 3.
Correlation between lumbar bone mineral density levels and clinical variables among hemodialysis patients.
| Variables | Lumbar bone mineral density (g/cm2) | ||||
|---|---|---|---|---|---|
| Simple linear regression | Multivariable linear regression | ||||
| R | P value | Beta | Adjusted R2 change | P value | |
| Female | −0.490 | <0.001∗ | −0.256 | 0.048 | 0.001∗ |
| Age (years) | −0.321 | 0.001∗ | −0.181 | 0.044 | 0.012∗ |
| Log-HD duration (months) | −0.089 | 0.382 | — | — | — |
| Height (cm) | 0.531 | <0.001∗ | — | — | — |
| Pre-HD body weight (kg) | 0.570 | <0.001∗ | 0.219 | 0.325 | 0.008∗ |
| Waist circumference (cm) | 0.429 | <0.001∗ | — | — | — |
| Body mass index (kg/m2) | 0.418 | <0.001∗ | — | — | — |
| Systolic blood pressure (mmHg) | 0.105 | 0.305 | — | — | — |
| Diastolic blood pressure (mmHg) | 0.011 | 0.913 | — | — | — |
| Total cholesterol (mg/dL) | −0.076 | 0.456 | — | — | — |
| Log-triglyceride (mg/dL) | 0.220 | 0.029∗ | — | — | — |
| Log-glucose (mg/dL) | 0.084 | 0.409 | — | — | — |
| Albumin (mg/dL) | 0.239 | 0.018∗ | 0.148 | 0.017 | 0.044∗ |
| Globulin (mg/dL) | −0.029 | 0.780 | — | — | — |
| Blood urea nitrogen (mg/dL) | 0.037 | 0.715 | — | — | — |
| Creatinine (mg/dL) | 0.220 | 0.029∗ | — | — | — |
| Total calcium (mg/dL) | 0.005 | 0.957 | — | — | — |
| Phosphorus (mg/dL) | 0.123 | 0.229 | — | — | — |
| Log-iPTH (pg/mL) | −0.127 | 0.214 | — | — | — |
| Log-leptin (ng/mL) | 0.568 | <0.001∗ | 0.483 | 0.184 | <0.001∗ |
| Urea reduction rate | −0.382 | <0.001∗ | — | — | — |
| Kt/V (gotch) | -0.380 | <0.001∗ | — | — | — |
Data of triglyceride, glucose, iPTH, and leptin levels showed skewed distribution and therefore were log-transformed before the analysis. Analysis of data was performed using the simple linear regression analysis or multivariable stepwise linear regression analysis (adapted factors were gender, age, height, pre-HD body weight, waist circumference, body mass index, log-triglyceride, albumin, creatinine, log-leptin, urea reduction rate, and Kt/V). HD, hemodialysis; iPTH, intact parathyroid hormone; Kt/V, fractional clearance index for urea. ∗P < 0.05 was considered statistically significant.