Figure 1.

The behavioral phenotype of female HAB and LAB rats. (a) Percentage of time spent on the open arms of the elevated plus-maze, as an indicator of anxiety-like behavior; (b) Feeding latency shown in the novelty-suppressed feeding paradigm, as an indicator of depressive-like behavior; (c,d) Percentage of investigation time of the empty cage, the same and the novel female rat shown during the first (c) and second (d) 5 min of the social preference test, as indicators of social anxiety-like behavior and social recognition, respectively. Female HAB rats showed an anxious and depressive-like phenotype compared with LAB rats but unaltered social anxiety and social recognition. Data represent individual data points with means ± SEM. * p < 0.05.