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Hemodynamic studies of PAH without or with silibinin treatment. (A,B) Silibinin did not decrease RVSP (A) and the Fulton index (B) after two weeks of treatment in the normal-silibinin group compared to the normal-control group. (C,D) Silibinin significantly decreased RVSP (C) and the Fulton index (D) after two weeks of treatment in the PAH-silibinin group compared to the PAH-control group. * p < 0.05. Each group consisted of four rats.
