Figure 1.
NPR1 expression levels in different types of cancer and their normal tissues. (a) Expression of NRP1 in different type of cancer using the Oncomine database. The graph shows the numbers of datasets with mRNA up-regulated expression (red) or down-regulated expression (blue). The threshold was designed with following parameters: p-value of 1 × 10−4 and fold change of 2. (b) The GEPIA2 database was used to determine NRP1 mRNA expression in various types of cancer. The dot plots present mRNA expression data from each cancer and normal tissues that were profiled. Red dots represent tumor tissues, green dots represent normal tissues, and black dots represent the average value of all tumor and normal tissues. The red label indicates that NRP1 is upregulated in cancer compared to normal tissue and green indicates downregulation. The black label indicates no significant difference between the tumor and normal tissue. Abbreviations of cancer types are presented in Supplementary Table S1. (c) Expression of NRP1 in various types of cancer and normal tissues is displayed using the TIMER website. Datasets of normal and cancer tissues were obtained from the TCGA database. * P < 0.05, ** P < 0.01, *** P < 0.001.