Table 1.
Correlation analysis between NRP1 and gene markers of immune cells using TIMER.
| Description | Gene Markers | STAD | LUAD | ||||||
|---|---|---|---|---|---|---|---|---|---|
| None | Purity | None | Purity | ||||||
| Cor | P | Cor | P | Cor | P | Cor | P | ||
| T cell (general) | CD3D | 0.306 | *** | 0.273 | *** | 0.143 | * | 0.101 | 0.024 |
| CD3E | 0.333 | *** | 0.39 | *** | 0.155 | ** | 0.117 | * | |
| CD2 | 0.382 | *** | 0.36 | *** | 0.168 | ** | 0.127 | * | |
| Treg cell | FOXP3 | 0.363 | *** | 0.336 | *** | 0.233 | *** | 0.203 | *** |
| CCR8 | 0.495 | *** | 0.482 | *** | 0.331 | *** | 0.317 | *** | |
| STAT5B | 0.579 | 0 | 0.574 | *** | 0.364 | *** | 0.358 | *** | |
| TGFβ (TGFB1) | 0.596 | *** | 0.576 | *** | 0.458 | 0 | 0.444 | *** | |
| TAM | CCL2 | 0.501 | 0 | 0.472 | *** | 0.247 | *** | 0.227 | *** |
| CD68 | 0.414 | 0 | 0.384 | *** | 0.256 | *** | 0.247 | ** | |
| IL10 | 0.551 | *** | 0.534 | *** | 0.197 | *** | 0.177 | * | |
| M1 Macrophage | INOS(NOS2) | −0.001 | 0.976 | −0.013 | 0.803 | 0.151 | ** | 0.127 | * |
| IRF5 | 0.313 | *** | 0.301 | *** | 0.206 | *** | 0.183 | *** | |
| COX2 (PTGS2) | 0.279 | *** | 0.258 | *** | 0.192 | *** | 0.207 | ** | |
| M2 Macrophage | CD163 | 0.662 | 0 | 0.642 | *** | 0.365 | *** | 0.363 | *** |
| VSIG4 | 0.607 | 0 | 0.601 | *** | 0.290 | *** | 0.279 | *** | |
| MS4A4A | 0.656 | 0 | 0.644 | *** | 0.309 | *** | 0.303 | *** | |
| CD8+ T cell | CD8A | 0.365 | *** | 0.339 | *** | 0.156 | ** | 0.129 | * |
| CD8B | 0.220 | *** | 0.202 | *** | 0.077 | 0.081 | 0.049 | 0.280 | |
| Neutrophil | CD66b(CEACAM8) | 0.102 | 0.036 | 0.115 | 0.025 | 0.193 | *** | 0.183 | *** |
| CD11b (ITGAM) | 0.614 | 0 | 0.598 | *** | 0.367 | *** | 0.357 | *** | |
| CCR7 | 0.427 | 0 | 0.403 | *** | 0.157 | ** | 0.119 | * | |
| NK cell | KIR2DL1 | 0.250 | *** | 0.256 | *** | 0.015 | 0.725 | −0.003 | 0.939 |
| KIR2DL3 | 0.180 | *** | 0.169 | *** | 0.089 | 0.043 | 0.069 | 0.123 | |
| KIR2DL4 | 0.113 | 0.02 | 0.086 | 0.091 | 0.068 | 0.122 | 0.044 | 0.324 | |
| KIR3DL1 | 0.219 | *** | 0.210 | *** | 0.021 | 0.629 | −0.011 | 0.810 | |
| KIR3DL2 | 0.204 | *** | 0.202 | *** | 0.122 | 0.005 | 0.100 | 0.026 | |
| KIR3DL3 | −0.001 | 0.991 | 0.022 | 0.667 | 0.064 | 0.145 | 0.042 | 0.352 | |
| KIR2DS4 | 0.162 | *** | 0.161 | * | 0.093 | 0.034 | 0.065 | 0.151 | |
| B cell | CD19 | 0.259 | *** | 0.230 | *** | −0.008 | 0.850 | −0.057 | 0.203 |
| CD79A | 0.263 | *** | 0.219 | *** | 0.040 | 0.369 | 0.004 | 0.925 | |
| Monocyte | CD86 | 0.575 | *** | 0.563 | *** | 0.340 | *** | 0.332 | *** |
| CD115 (CSF1R) | 0.664 | 0 | 0.647 | *** | 0.374 | *** | 0.357 | *** | |
| T cell exhaustion | PD1 (PDCD1) | 0.266 | *** | 0.245 | *** | 0.157 | ** | 0.127 | * |
| CTLA4 | 0.289 | *** | 0.265 | *** | 0.186 | *** | 0.152 | ** | |
| LAG3 | 0.249 | *** | 0.218 | *** | 0.076 | 0.086 | 0.043 | 0.343 | |
| TIM3 (HAVCR2) | 0.569 | 0 | 0.553 | *** | 0.309 | *** | 0.296 | *** | |
STAD, Stomach Adenocarcinoma; LUAD, Lung Adenocarcinoma; Treg, regulatory T cell; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Cor, P value of Spearman’s correlation; None, correlation without adjustment; Purity, correlation adjusted by purity. * P < 0.01; ** P < 0.001; *** P < 0.0001.