Table 1.
Comparison of clinical prediction models for recurrent venous thromboembolism.
Score | Variables | Inclusion Criteria | Definition of Unprovoked VTE | Findings—Risk of Recurrent VTE |
---|---|---|---|---|
DASH [11] | Abnormal D-dimer after AC Age ≤ 50 Gender Hormone therapy |
First unprovoked VTE |
Absence of: Surgery Trauma Active cancer Immobility Pregnancy and puerperium Included: Hormone therapy Thrombophilic blood abnormality (if no other VTE risks) |
Annualised recurrence risk: Score ≤ 1:3.1% Score > 1:9.3% |
HERDOO2 [8] | Gender Signs of post-thrombotic syndrome Abnormal D-dimer during on AC BMI ≥ 30 Age ≥ 65 |
First unprovoked VTE after 5–12 months of AC |
Absence of: Major surgery within 3 months Malignancy within 5 years Immobilisation for ≥ 3 days Leg fracture or plaster cast Included: Travel-related Exogenous oestrogen Minor immobilisation Minor surgery |
Annualised recurrence risk: Low-risk (0 or 1 factor) females: 1.6% High-risk (≥ 2 factors) females: 14.1% per year Males (no low-risk group identified): 13.7% |
Vienna [9] | Gender VTE location D-dimer after ceasing AC |
First unprovoked VTE after at least 3 months of AC |
Absence of: Major surgery Major trauma Pregnancy Female hormone intake Hereditary thrombophilia Malignancy Included: Immobility |
Continuous HR based on nomogram |
BMI: body mass index; HR: hazard ratio; AC: anticoagulation; VTE: venous thromboembolism.