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. 2020 May 16;9(5):1238. doi: 10.3390/cells9051238

Figure 6.

Figure 6

TDP-43 regulates neflb splicing in zebrafish. (A) left, PCR analysis on RNA extracted from St Ctrl embryos and fish KD for TDP-43, using specific primers for both isoforms neflbE4 and neflbE3. Right, quantification of the neflbE3 and neflbE4 ratio. (B), axonal length measurement at 48 hpf after the overexpression of eGFP-neflbE4 and eGFP-neflbE3 constructs in KD TDP-43 embryos. neflbE4 significantly rescued the axon length (middle histo bar), whereas neflbE3 significantly aggravated the KD TDP-43 phenotype (right histo bar). * p < 0.05, *** p < 0.001, in comparison to TDP-43 Mo + eGFP.