Table 1.
Baseline characteristics of the study cohort before liver transplantation.
| Clinical Parameters | cfDNA Low (90 bp) n = 41 |
cfDNA High (90 bp) n = 9 |
p-Value |
|---|---|---|---|
| Age (years) | 57 (22−70) | 61 (28−65) | 0.946 |
| Sex | 0.454 | ||
| Female | 15 | 5 | |
| Male | 26 | 4 | |
| BMI (kg/m2) | 25.0 (17.3−40.0) | 28.6 (19.4−37.9) | 0.393 |
| Primary disease | |||
| Hepatocellular carcinoma | 14 | 2 | 0.573 |
| Cholangiocellular carcinoma | 2 | 1 | 0.844 |
| Alcoholic cirrhosis | 7 | 0 | 0.213 |
| Primary sclerosing cholangitis | 4 | 2 | 0.217 |
| Viral cirrhosis | 4 | 1 | 0.257 |
| Cryptogenic cirrhosis | 3 | 1 | 0.608 |
| Other | 8 | 2 | 0.699 |
| labMELD | 15 (6−40) | 19 (6−40) | 0.713 |
| International normalised ratio | 1.37 (0.97−5.3) | 1.35 (0.99−2.14) | 0.945 |
| Bilirubin total (mg/dL) | 2.1 (0.3−30.3) | 4.7 (0.5−20.2) | 0.838 |
| Creatinine (mg/dL) | 0.80 (0.47−4.67) | 0.82 (0.48−4.0) | 0.925 |
| Sodium (mmol/L) | 138 (128−144) | 138 (129−142) | 0.300 |
Listed laboratory results were determined before transplantation. cfDNA was determined in blood plasma taken immediately after transplantation (when patients arrived at the ICU). Continuous values are presented as median values and categorical values as numbers. Continuous variables were assumed to be non-normally distributed, and were tested using the Kruskal–Wallis test or Mann–Whitney U test for pairwise analyses. The χ2 test or Fisher’s exact test was used to test univariate differences between categorical variables.