Table 4.

Most recurrent genetic alterations in oesophagal and gastroesophageal cancers.

Esophageal Cancer		Gastroesophageal Cancer
Gene	Frequency (%)	Gene	Frequency (%)
TP53	60–93	TP53	14–59
CCND1	33–46	PIK3CA	7–36
CDKN2A	12–47	CDH1	4–36
KMT2D	19–26	HER2	2–32
FAT1	14–27	ARID1A	8–27
KRAS	5–27	KRAS	0–27
EGFR	6–24	PTEN	0–27
NOTCH	9–19	RHOA	0–23
PIK3CA	4–10	APC	3–14
		ERBB3	0–10
		CTNNB1	2–9
		MET	0–9
		SMAD4	4–6
		FBXW7	2–6