Table 1.
Baseline characteristics of the patients.
| Characteristic | F ≤ 2 (N = 39) | F = 3 (N = 6) | P-Value |
|---|---|---|---|
| Male (%) | 23 (59.0) | 2 (33.3) | 0.462 |
| Age, year | 41.0 (33.5–54.5) | 60.5 (57.0–64.0) | 0.015 * |
| Steatosis | 0.284 | ||
| 5–33% (%) | 13 (33.3) | 4 (66.7) | |
| >33–66% (%) | 16 (41.0) | 1 (16.7) | |
| >66% (%) | 10 (25.6) | 1 (16.7) | |
| Lobular inflammation | 0.496 | ||
| <2 foci per 200 × field (%) | 25 (64.1) | 4 (66.7) | |
| 2–4 foci per 200 × field (%) | 12 (30.8) | 1 (16.7) | |
| >4 foci per 200 × field (%) | 2 (5.1) | 1 (16.7) | |
| Ballooning | 0.144 | ||
| None (%) | 8 (20.5) | 0 (0.0) | |
| Few ballooned cells (%) | 20 (51.3) | 2 (33.3) | |
| Many cells/prominent ballooning (%) | 11 (28.2) | 4 (66.7) | |
| Nonalcoholic steatohepatitis | 31 (79.5) | 6 (100.0) | 0.516 |
| NAS ≥ 5 (%) | 17 (43.6) | 4 (66.7) | 0.538 |
| Weight, kg | 79.0 (70.0–97.0) | 72.0 (59.3–84.0) | 0.226 |
| BMI, kg/m2 | 27.8 (26.1–32.4) | 27.9 (26.5–30.4) | 0.694 |
| Systolic blood pressure, mmHg | 138 (127–148) | 132.0 (132–133) | 0.573 |
| Hypertension | 19 (48.7) | 4 (66.7) | 0.704 |
| Diabetes | 10 (25.6) | 5 (83.3) | 0.020 * |
| Platelets, ×103/mm | 240.0 (200.0–286.0) | 167.0 (142.0–192.0) | 0.023 |
| AST, IU/L | 63.0 (51.5–82.0) | 119.0 (74.0–165.0) | 0.019 * |
| ALT, IU/L | 96.0 (70.5–128.5) | 76.0 (58.0–173.0) | 0.593 |
| Bilirubin, mg/dL | 0.6 (0.5–0.7) | 0.7 (0.7–0.9) | 0.681 |
| Albumin, g/dL | 4.6 (4.4–4.8) | 4.5 (4.1–4.7) | 0.350 |
| Gamma GTP, mg/dL | 60.0 (46.0–123.0) | 61.0 (52.0-92.0) | 0.820 |
| Creatinine, mg/dL | 0.8 (0.7–0.9) | 0.7 (0.7–0.9) | 0.494 |
| Fasting blood glucose, mg/dL | 108.0 (98.0–123.0) | 118.5 (113.0–127.0) | 0.142 |
| Total cholesterol, mg/dL | 183.0 (164.0–204.0) | 167.5 (160.0–211.0) | 0.687 |
| HDL, mg/dL | 38.5 (31.0–49.0) | 48.5 (43.0–56.0) | 0.098 |
| LDL, mg/dL | 118.5 (93.0–145.0) | 108.5 (100.0–151.0) | 0.857 |
| Triglyceride, mg/dL | 183.0 (123.0–295.0) | 102.0 (70.0–118.0) | 0.005 * |
NAS, nonalcoholic fatty liver disease activity score; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GTP, guanosine triphosphate; HDL, high density lipoprotein; LDL, low density lipoprotein. * P-value < 0.05.