Table 3.

Diagnostic values of biomarkers for RA.

Combination of Biomarkers	Sensitivity (%)	Specificity (%)	PPV	NPV	Diagnostic Accuracy
anti-CCP Abs	66.7	76.6	52.2	85.7	73.8
RF	61.1	87.2	64.7	85.4	80.0
IL-15	77.8	80.9	60.9	90.5	80.0
IL-15 or anti-CCP Abs	83.3	63.8	46.9	90.9	69.2
IL-15 or RF	77.8	70.2	50.0	89.2	72.3
IL-15 and anti-CCP Abs	61.1	93.6	78.6	86.3	84.6
IL-15 and RF	61.1	97.9	91.7	86.8	87.7
IL-15 and anti-CCP Abs and RF	55.6	97.9	90.9	85.2	86.2
anti-CCP Abs and RF	55.6	91.5	71.4	84.3	81.5
anti-CCP Abs or RF	72.2	72.3	50.0	87.2	72.3
IL-15 or anti-CCP Abs or RF	83.3	59.6	44.1	90.3	66.2

Abbreviations: PPV: positive predictive value; NPV: negative predictive value.