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Poly-lactic-co-glycolic-acid (PLGA) transient carriers field emission-scanning electron microscopy (FE-SEM) image, particle size distribution, and ihGDF-5 release profile. FE-SEM images indicated spherical morphology of carriers (a); the size distribution set at 230 ± 80 nm their mean size (b). Release profiles performed in vitro at 37 °C indicated a ihGDF-5 mean concentration of 1.6 ng/mL/day released from the 100 mg of PLGA-NCs loaded within HY-FIB over 11 days of culture (c).
