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TC+M-FISH used to detect a complex karyotype in a case of acute lymphoblastic leukemia. This approach makes it possible to detect not only the translocation and complex exchange, but also the presence of a specific configuration of dicentric chromosomes with both the centromeres juxtaposed, such as dic(5;21)(p10;p10) and dic(21;22)(p10;p10) (arrow yellow and cyanine), or when the distance between both centromeres is very small (dic(10;17)(p10; p11).
