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The presence of dicentric chromosome is associated with telomere dysfunction and complex karyotypes. Sequential analysis shows the presence of clonal dicentric chromosomes and centric rings in a mantle-cell lymphoma patient. These configurations are related to the presence of chromosomal aberrations related to breakage–fusion–bridge cycles, such as der(18) t (18,11;5) with an interstitial telomere of chromosome 18 and der(22) t (22;3;17;11;3;11).
