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. Author manuscript; available in PMC: 2020 Jun 12.
Published in final edited form as: Gastroenterology. 2020 Jan 7;158(5):1359–1372.e9. doi: 10.1053/j.gastro.2019.12.027

Figure 2.

Figure 2.

FFAR2 deficiency increases exhausted CD8+ T cells in colon tumors. (A) Flow cytometric analysis of tumor CD39+CD8+ cell frequency in ApcMin/+ (N = 10) and ApcMin/+Ffar2−/− (N = 13) mice. (B) Tumor PD-1+CD8+ T-cell frequency in ApcMin/+ (N = 10) and ApcMin/+Ffar2−/− (N = 13) mice. (C) Tumor LAG-3+CD8+ T-cell frequency in ApcMin/+ (N = 4) and ApcMin/+Ffar2−/− (N = 7) mice. (D) Tumor live CD3+CD8+ T-cell frequency in ApcMin/+ (N = 8) and ApcMin/+Ffar2−/− (N = 8) mice. (E) Frequency of dead CD3+CD8+ T cells in tumors from ApcMin/+ (N = 8) and ApcMin/+ IFNG+ Ffar2−/− (N = 8) mice. (F) Tumor Data from A–F are from Min/+Ffar2−/− (N = 12) mice. cell frequency out of CD39+CD8+ cells in ApcMin/+ (N = 7) and Apc ≥3 independent experiments and are plotted as mean ± SEM. *P < .05, unpaired t test.