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. Author manuscript; available in PMC: 2020 Jun 12.
Published in final edited form as: Gastroenterology. 2020 Jan 7;158(5):1359–1372.e9. doi: 10.1053/j.gastro.2019.12.027

Figure 5.

Figure 5.

Conditional deletion of FFAR2 from DCs contributes to tumorigenesis after colon barrier disruption. (A) Colon LP PD1+CD8+ T-cell frequency from ApcMin/+Ffar2fl/fl (N = 4) mice given DSS vs ApcMin/+Ffar2fl/flCD11c-Cre (N = 4) mice given DSS and killed on day 10. (B) Colon LP IL27+ DC frequency from ApcMin/+Ffar2fl/fl (N = 4) vs ApcMin/+Ffar2fl/flCD11c-Cre (N = 4) mice given DSS and killed on day 10. (C) Tumor number in ApcMin/+Ffar2fl/fl (N = 9) vs ApcMin/+Ffar2fl/flCD11c-Cre (N = 7) mice given DSS and killed on day 21. Data from A and B are from 2 independent experiments. Data from C are from 3 independent experiments. Data from A–C are plotted as mean ± SEM. *P ≤ .05, Mann–Whitney U test.