Figure 2.

Multifunctional roles of caveolae/CAV-1 in the life cycle of corresponding viruses. (A) Trafficking: CAV-1 is involved in the complicated trafficking network of viruses. There is host cell type-, virus type-dependent crosstalk between caveosome trafficking and endosome trafficking, despite different endocytic pathways (caveolae- or clathrin-mediated) that viruses hijack. In addition to viral particles, CAV-1 is also involved in regulating the sorting and transport of viral components/proteins. (B) Replication: caveolae and CAV-1 facilitate the targeted location of virions, viral proteins, and host-related proteins to lipid rafts-associated compartments to complete viral replication. (C) Assembly and egress: caveolae and CAV-1 are involving in virus release and might incorporate into the enveloping process of some mature virus particles. The chromatic wireframes indicate the reported viruses involved in these processes. Numbers in square brackets indicate the relative references.