Table 4.
Monitored AF event rates, in relation to C2HEST score and risk strata, among population age 18–39, age 40–54, age 55–64 and age ≥65. (A) Suspected AF. (B) Confirmed AF.
| (A) Suspected AF. | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Detected AF (n = 739) | Age 18–39 (n = 145,389) | Age 40–54 (n = 52,089) | Age 55–64 (n = 8716) | Age ≥ 65 (n = 3080) | ||||||||||||
| C2HEST | AF | Number, n | Rate, % | HR (95%CI) | AF | Number, n | Rate, % | HR (95%CI) | AF | Number, n | Rate, % | HR (95%CI) | AF | Number, n | Rate,% | HR (95% CI) |
| 0 | 55 | 94,605 | 0.06% | 1.00 (reference) | 82 | 22,837 | 0.36% | 1.00 (reference) | 28 | 2902 | 0.96% | 1.00 (reference) | 21 | 677 | 3.10% | 1.00 (reference) |
| 1 | 39 | 41,772 | 0.09% | 1.59 (1.06–2.40) | 107 | 20,075 | 0.53% | 1.48 (1.11–1.98) | 58 | 3252 | 1.78% | 1.83 (1.17–2.88) | 37 | 859 | 4.31% | 1.38 (0.80–2.36) |
| 2 | 19 | 7548 | 0.25% | 4.29 (2.54–7.23) | 55 | 7745 | 0.71% | 1.98 (1.41–2.79) | 51 | 1895 | 2.69% | 2.79 (1.76–4.43) | 40 | 765 | 5.23% | 1.64 (0.97–2.79) |
| 3 | 6 | 1031 | 0.58% | 10.18 (4.38–23.64) | 18 | 1040 | 1.73% | 4.90 (2.94–8.17) | 25 | 469 | 5.33% | 5.58 (3.25–9.57) | 32 | 419 | 7.64% | 2.48 (1.42–4.30) |
| 4 | 1 | 235 | 0.43% | 7.54 (1.04–54.46) | 8 | 225 | 3.56% | 10.03 (4.85–20.73) | 10 | 123 | 8.13% | 8.66 (4.21–17.84) | 15 | 198 | 7.58% | 2.34 (1.20–4.55) |
| 5 | 0 | 62 | 0.00% | - | 4 | 119 | 3.36% | 9.38 (3.44–25.60) | 2 | 66 | 3.03% | 3.19 (0.76–13.39) | 14 | 109 | 12.84% | 4.69 (2.38–9.22) |
| 6+ | 1 | 136 | 0.74% | 13.18 (1.82–95.29) | 2 | 48 | 4.17% | 11.94 (2.93–48.57) | 1 | 9 | 11.11% | 11.21 (1.52–82.43) | 8 | 53 | 15.09% | 5.06 (2.24–11.44) |
| Low 0–1 | 94 | 136,377 | 0.07% | 1.00 (reference) | 189 | 42912 | 0.44% | 1.00 (reference) | 86 | 6154 | 1.40% | 1.00 (reference) | 58 | 1536 | 3.78% | 1.00 (reference) |
| Intermediate 2–3 | 25 | 8579 | 0.29% | 4.21 (2.71–6.54) | 73 | 8785 | 0.83% | 1.89 (1.44–2.48) | 76 | 2364 | 3.21% | 2.31 (1.70–3.15) | 72 | 1184 | 6.08% | 1.59 (1.13–2.26) |
| High > 3 | 2 | 433 | 0.46% | 6.86 (1.69–27.83) | 14 | 392 | 3.57% | 8.19 (4.76–14.10) | 13 | 198 | 6.57% | 4.81 (2.68–8.63) | 37 | 360 | 10.28% | 2.78 (1.84–4.21) |
| p for trend | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
| (B) Confirmed AF. | ||||||||||||||||
| Confirmed AF (n = 374) | Age 18–39 (n = 145,389) | Age 40–54 (n = 52,089) | Age 55–64 (n = 8716) | Age ≥ 65 (n = 3080) | ||||||||||||
| C2HEST | AF | Number, n | Rate, % | HR (95%CI) | AF | Number, n | Rate, % | HR (95% CI) | AF | Number, n | Rate,% | HR (95%CI) | AF | Number, n | Rate, % | HR (95% CI) |
| 0 | 22 | 94,605 | 0.02% | 1.00 (reference) | 41 | 22,837 | 0.18% | 1.00 (reference) | 16 | 2902 | 0.55% | 1.00 (reference) | 7 | 677 | 1.03% | 1.00 (reference) |
| 1 | 17 | 41,772 | 0.04% | 1.74 (0.92–3.28) | 53 | 20,075 | 0.26% | 1.47 (0.98–2.21) | 31 | 3252 | 0.95% | 1.72 (0.94–3.14) | 23 | 859 | 2.68% | 2.58 (1.10–6.02) |
| 2 | 8 | 7548 | 0.11% | 4.52 (2.01–10.15) | 22 | 20,075 | 0.11% | 1.59 (0.94–2.66) | 31 | 1895 | 1.64% | 2.97 (1.62–5.43) | 24 | 765 | 3.14% | 2.93 (1.26–6.81) |
| 3 | 2 | 1031 | 0.19% | 8.43 (1.98–35.87) | 11 | 1040 | 1.06% | 5.99 (3.08–11.65) | 15 | 469 | 3.20% | 5.88 (2.90–11.89) | 17 | 419 | 4.06% | 3.89 (1.61–9.40) |
| 4 | 0 | 235 | 0.00% | - | 2 | 225 | 0.89% | 5.03 (1.21–20.79) | 7 | 123 | 5.69% | 10.56 (4.34–25.68) | 5 | 198 | 2.53% | 2.26 (0.71–7.17) |
| 5 | 0 | 62 | 0.00% | - | 3 | 119 | 2.52% | 14.08 (4.36–45.49) | 2 | 66 | 3.03% | 5.54 (1.27–24.11) | 8 | 109 | 7.34% | 8.23 (2.98–22.72) |
| 6+ | 0 | 136 | 0.00% | - | 1 | 48 | 2.08% | 11.90(1.63–86.52) | 1 | 9 | 11.11% | 19.45 (2.58–146.73) | 5 | 53 | 9.43% | 9.47 (3.00–29.84) |
| Low 0–1 | 39 | 136,377 | 0.03% | 1.00 (reference) | 94 | 42,912 | 0.22% | 1.00 (reference) | 47 | 6154 | 0.76% | 1.00 (reference) | 30 | 1536 | 1.95% | 1.00 (reference) |
| Intermediate 2–3 | 10 | 8579 | 0.12% | 4.06 (2.02–8.12) | 33 | 8785 | 0.38% | 1.72 (1.15–2.56) | 46 | 2364 | 1.95% | 2.56 (1.70–3.85) | 41 | 1184 | 3.46% | 1.74 (1.08–2.79) |
| High > 3 | 0 | 433 | 0.00% | - | 6 | 392 | 1.53% | 7.07 (3.09–16.14) | 10 | 198 | 5.05% | 6.73 (3.40–13.33) | 18 | 360 | 5.00% | 2.59 (1.44–4.67) |
| p for trend | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
HR, hazard ratio. CI, confidential interval.