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Substrates for aminoacylation ribozymes. Phenylalanyl-adenosine monophosphate74,78 (1), biocytinCoA76 (2), biotinyl-Tyr(Me)-oxazolone77 (3), amino acid cyanomethyl ester,90 (4) and amino acid 3,5-dinitrobenzyl ester90 (5). Substrates 4 and 5 are flexizyme substrates. The amino acid backbone is depicted in green; side chains are depicted in blue, and leaving groups are depicted in red. R indicates possible chemical variation in the side chain.
