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. 2020 Jun 5;11:505. doi: 10.3389/fneur.2020.00505

Figure 3.

Figure 3

Effect of UVN on rat activity and spatial exploration in an open field. (A) Movement tracing and spatial exploration pattern (Heatmaps) of UVN and Sham rats in an open field over the 10 min analysis period. Heatmaps indicate the cumulative time at place (blue to red scale increasing duration). (B) Curve illustrating the mean postoperative recovery of the distance moved by rats on the open-field in the two experimental group of rats (Sham in black and UVN in red). (C) Curve illustrating the mean postoperative recovery of meander by rats on the open-field in the two experimental group of rats (Sham in black and UVN in red). Data represent mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001. (D) Zoom on the movement tracing of a UVN rat 1 and 7 days after the surgery. Meander is defined as “the change in direction of movement of a subject relative to the distance moved by that subject and provides an indication of how convoluted the subject's trajectory is.” As observed on the movement tracing by rats 1 day after the surgery the trajectory (arrow) of the animal is more “tortuous” compared to the trajectory of the same rat seven days after UVN. A significant difference from the pre-operative value is indicated by * in black for the SHAM group. A significant difference from the pre-operative value is indicated by * in red for the UVN group. A significant difference between the SHAM and the UVN group is indicated with * in blue.