Table 1.
Natural polypeptides having activity against elastase and their IC50s.
| Compound | Name | IC50 against HNE/µM | IC50 against PPE/µM | Reference | |
|---|---|---|---|---|---|
| Anti-elastase polypeptides of bacterial origin | 1 | Lyngbyastatin 4 | 0.049 | 0.03 | (Matthew et al., 2007; Salvador et al., 2013) |
| In another study, 0.04 | |||||
| 2 | Lyngbyastatin 5 | 0.0032 | (Taori et al., 2007; Salvador et al., 2013) | ||
| 3 | Lyngbyastatin 6 | 0.0033 | (Taori et al., 2007; Salvador et al., 2013) | ||
| 4 | Lyngbyastatin 7 | 0.0023 | 0.0083 | (Taori et al., 2007; Salvador et al., 2013) | |
| In another study, 0.003 | |||||
| 5 | Somamide B | 0.0095 | 0.0095 | (Taori et al., 2007; Salvador et al., 2013) | |
| 6 | Lyngbyastatin 8 | 0.123 | (Kwan et al., 2009) | ||
| 7 | Lyngbyastatin 9 | 0.210 | (Kwan et al., 2009) | ||
| 8 | Lyngbyastatin 10 | 0.120 | (Kwan et al., 2009) | ||
| 9 | Bouillomide A | 1.9 | (Rubio et al., 2010) | ||
| 10 | Bouillomide B | 1.9 | (Rubio et al., 2010) | ||
| 11 | Kempopeptin A | 0.3 | (Taori et al., 2008) | ||
| 12 | Tiglicamide A | 2.1 | (Matthew et al., 2009b) | ||
| 13 | Tiglicamide B | 6.9 | (Matthew et al., 2009b) | ||
| 14 | Tiglicamide C | 7.3 | (Matthew et al., 2009b) | ||
| 15 | Largamide A | 1.4 | (Matthew et al., 2009a) | ||
| 16 | Largamide B | 0.5 | (Matthew et al., 2009a) | ||
| 17 | Largamide C | 1.2 | (Matthew et al., 2009a) | ||
| 18 | Symplostatin 5 | 0.068 | (Salvador et al., 2013) | ||
| 19 | Symplostatin 6 | 0.089 | (Salvador et al., 2013) | ||
| 20 | Symplostatin 7 | 0.077 | (Salvador et al., 2013) | ||
| 21 | Symplostatin 8 | 0.041 | 0.043 | (Salvador et al., 2013) | |
| 22 | Symplostatin 9 | 0.028 | 0.037 | (Salvador et al., 2013) | |
| 23 | Symplostatin 10 | 0.021 | 0.044 | (Salvador et al., 2013) | |
| 24 | Stigonemapeptin | 0.3 | (Kang et al., 2012) | ||
| 25 | Oscillapeptin | 2.5 | (Shin et al., 1995) | ||
| 26 | Oscillapeptin A | 2.5 | (Itou et al., 1999) | ||
| 27 | Oscillapeptin B | 4.2 | (Itou et al., 1999) | ||
| 28 | Oscillapeptin D | 2.6 | (Itou et al., 1999) | ||
| 29 | Oscillapeptin E | 2.7 | (Itou et al., 1999) | ||
| 30 | Oscillapeptin G | 1.0 | (Fujii et al., 2000) | ||
| 31 | Oscillapeptilide 97-A | 6.9 | (Fujii et al., 2000) | ||
| 32 | Oscillapeptilide 97-B | 3.9 | (Fujii et al., 2000) | ||
| 33 | Microviridin I | 1.9 | (Fujii et al., 2000) | ||
| 34 | Microviridin G | 1.0 | (Murakami et al., 1997) | ||
| 35 | Microviridin H | 1.7 | (Murakami et al., 1997) | ||
| 36 | Nostopeptin A | 1.3 | (Okino et al., 1997) | ||
| 37 | Nostopeptin B | 1.2 | (Okino et al., 1997) | ||
| 38 | Insulapeptolide A | 0.1 | (Mehner et al., 2008) | ||
| 39 | Insulapeptolide B | 0.1 | (Mehner et al., 2008) | ||
| 40 | Insulapeptolide C | 0.09 | (Mehner et al., 2008) | ||
| 41 | Insulapeptolide D | 0.08 | (Mehner et al., 2008) | ||
| 42 | Insulapeptolide E | 3.2 | (Mehner et al., 2008) | ||
| 43 | Insulapeptolide F | 1.6 | (Mehner et al., 2008) | ||
| 44 | Insulapeptolide G | 3.5 | (Mehner et al., 2008) | ||
| 45 | Insulapeptolide H | 2.7 | (Mehner et al., 2008) | ||
| 46 | Microviridin C | 2.6 | (Okino et al., 1995) | ||
| 47 | Microviridin C | 4.8 | (Okino et al., 1995) | ||
| 48 | Micropeptin MM836 | 45.5 | (Zafrir-ilan and Carmeli, 2010) | ||
| 49 | Micropeptin MM932 | 4.4 | (Zafrir-ilan and Carmeli, 2010) | ||
| 50 | Micropeptin MM978 | 19.1 | (Zafrir-ilan and Carmeli, 2010) | ||
| 51 | Anabaenopeptin MM823 | 50.5 | (Zafrir-ilan and Carmeli, 2010) | ||
| 52 | anabaenopeptin MM850 | 14.3 | (Zafrir-ilan and Carmeli, 2010) | ||
| 53 | Micropeptin HH978 | 17.6 | (Lodin-Friedman and Carmeli, 2013) | ||
| 54 | Micropeptin HH960 | 55.5 | (Lodin-Friedman and Carmeli, 2013) | ||
| 55 | Micropeptin HH992 | 16.9 | (Lodin-Friedman and Carmeli, 2013) | ||
| 56 | micropeptin DR1006 | 13.0 | (Adiv et al., 2010) | ||
| 57 | Molassamide | 0.03 | (Gunasekera et al., 2010) | ||
| 58 | Scyptolin A | 1.6 | (Matern et al., 2001; Matern et al., 2003a) | ||
| 59 | Scyptolin B | 1.4 | (Matern et al., 2001; Matern et al., 2003a) | ||
| 60 | planktopeptin BL1125 | 0.096 | (Grach-pogrebinsky et al., 2003) | ||
| 61 | planktopeptin BL843 | 1.7 | (Grach-pogrebinsky et al., 2003) | ||
| 62 | planktopeptin BL1061 | 0.040 | (Grach-pogrebinsky et al., 2003) | ||
| 63 | brunsvicamide A | 3.1 | (Sisay et al., 2009) | ||
| 64 | Brunsvicamide B | 2.0 | (Sisay et al., 2009) | ||
| 65 | Brunsvicamide C | 4.4 | (Sisay et al., 2009) | ||
| 66 | FR901277 | 0.2 | 0.3 | (Nakanishi et al., 2000b) | |
| 67 | FR134043 | 0.04 | (Nakanishi et al., 2000a) | ||
| 68 | YM-47141 | 1.5 | (Orita et al., 1995; Yasumuro et al., 1995) | ||
| 69 | YM-47142 | 3.0 | (Orita et al., 1995; Yasumuro et al., 1995) | ||
| Anti-elastase polypeptide of plant origin | 70 | Ixorapeptide II | 5.6 | (Lee et al., 2010) | |
| Anti-elastase polypeptides of fungal origin | 71 | Desmethylisaridin C2 | 10.0 | (Chung et al., 2013) | |
| 72 | Isaridin E | 12.7 | (Chung et al., 2013) | ||
| 73 | Isaridin C2 | 12.1 | (Chung et al., 2013) | ||
| 74 | Roseocardin | 15.1 | (Chung et al., 2013) |