Table 2:
mRNA levels for HPV-associated genes in various primary and tumor tissues or cells
| Peripheral blood mononuclear cells | Epidermoid cell lines | Myeloid cell lines | Lymphoid cell lines | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Skin | Monocytes | T cells | B cells | NK cells | DCs | A431 | Hacat | HL-60 | THP-1 | U937 | MOLT4 | REH | |
| ADA | 2.8 | 64 | 10.3 | 1.3 | 16.9 | 41.6 | 1.4 | 0.2 | 0.6 | 1.9 | 3.3 | 197.1 | 10.6 |
| ADA2 | 2.5 | 46.4 | 7.9 | 6.1 | 9.5 | 29.8 | 0 | 0.3 | 0.2 | 5.8 | 20.7 | 20.5 | 0.4 |
| ATM | 8.4 | 12.5 | 18.5 | 13.7 | 7.6 | 6.1 | 2.6 | 4 | 10.2 | 5.8 | 11.3 | 7 | 5.5 |
| CARMIL2 | 0.4 | 0 | 2.7 | 1.5 | 1.7 | 1.1 | 0 | 0 | 2.4 | 0.6 | 0 | 21.6 | 36.4 |
| CD4 | 3.5 | 42.5 | 29.1 | 0.1 | 0.3 | 46.7 | 0 | 0 | 13.5 | 38.1 | 35.9 | 4.8 | 0 |
| CD40L | 1.1 | 0 | 29.2 | 0 | 0.2 | 0 | 0 | 0 | 0.1 | 0 | 0 | 22.4 | 0 |
| CIB1 | 10 | 45.4 | 55.2 | 87.9 | 35.9 | 43 | 24.5 | 25.5 | 31.9 | 19.3 | 36.5 | 24 | 13.6 |
| CORO1A | 3.4 | 67.5 | 66.4 | 41.6 | 39.1 | 67.7 | 0.2 | 0.4 | 59.6 | 34.7 | 75.5 | 57.6 | 31.3 |
| CXCR4 | 2.3 | 7.2 | 32 | 47.3 | 4 | 16.8 | 0.1 | 0 | 10.4 | 20.5 | 17.2 | 68.5 | 36.3 |
| DCLRE1C | 7.8 | 14.5 | 12.2 | 23.5 | 8 | 17.2 | 11.8 | 9.9 | 7.4 | 13.6 | 7.9 | 10.8 | 12.3 |
| DOCK8 | 3.3 | 21.5 | 5.5 | 7.3 | 6.6 | 15.4 | 0 | 0 | 16.8 | 50.6 | 10.6 | 15.7 | 19.8 |
| EVER1 | 6.5 | 26.7 | 27.2 | 13.5 | 15.6 | 8.3 | 5.4 | 9.7 | 11.7 | 17.8 | 19 | 5.7 | 2.6 |
| EVER2 | 1.7 | 6.6 | 13.1 | 5 | 6.7 | 2.1 | 0.1 | 1.1 | 20.4 | 4.2 | 17.3 | 7 | 0.4 |
| GATA2 | 4.1 | 0 | 0 | 0 | 0 | 0 | 4.6 | 4.9 | 6.9 | 2.8 | 0.4 | 0 | 0 |
| ICOS | 0.6 | 0 | 18.4 | 0 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 15.3 | 0 |
| IKBKG | 11.4 | 21.8 | 17.9 | 11.3 | 13.8 | 13.7 | 15.9 | 15 | 10.3 | 11.5 | 18.7 | 10.6 | 11.7 |
| IL2RG | 2.7 | 19.7 | 115.3 | 51.9 | 94.6 | 30.6 | 0.1 | 0.1 | 8.9 | 0.3 | 37 | 31.9 | 7.3 |
| IL7 | 9.6 | 0.8 | 7.5 | 10.9 | 0.5 | 2.4 | 0.2 | 3.3 | 0.1 | 0 | 0 | 0 | 0 |
| IL7R | 1.8 | 0.2 | 70.3 | 0.4 | 19.1 | 0.3 | 0.1 | 3.5 | 0.1 | 0 | 2 | 0.5 | 84.6 |
| ITGB2 | 4.1 | 122.9 | 57.4 | 9.5 | 41 | 76 | 0.2 | 0 | 15 | 114.8 | 85.3 | 17 | 0.2 |
| ITK | 1 | 0.6 | 28 | 0 | 9.2 | 0 | 0 | 0 | 0 | 0 | 0 | 21.7 | 0 |
| JAK3 | 1.3 | 9.6 | 15 | 7.4 | 8.4 | 4.5 | 0.1 | 0.1 | 0 | 1.3 | 13.7 | 3.6 | 4.6 |
| LCK | 1 | 0.3 | 112.2 | 6.1 | 42.8 | 0.5 | 0 | 0 | 0 | 0 | 0 | 98.9 | 3.8 |
| LIG4 | 6.6 | 10.7 | 2.7 | 3.3 | 2.7 | 2.1 | 9.4 | 3.9 | 10.2 | 15.7 | 5.9 | 16.8 | 15.5 |
| MAGT1 | 14.1 | 21.3 | 20.8 | 14.3 | 18.5 | 23.6 | 22.7 | 21.3 | 22.8 | 12.2 | 21.3 | 13.4 | 16.4 |
| NFKBIA | 48.2 | 58.3 | 37.3 | 45.3 | 33.2 | 55 | 12.9 | 17.1 | 6.1 | 13.1 | 4.6 | 8 | 18.3 |
| NLRP1 | 35.2 | 7.5 | 7 | 5.3 | 3.8 | 4.6 | 6.2 | 2.8 | 0 | 0.2 | 0.2 | 0 | 2.4 |
| PIK3CD | 2 | 15 | 13.7 | 8.4 | 14.5 | 14.5 | 2.6 | 0.8 | 18.4 | 22 | 26.3 | 1.7 | 22.7 |
| PIK3R1 | 19.1 | 4.1 | 14.8 | 2.2 | 8.2 | 2.1 | 1 | 2.6 | 6.7 | 4.8 | 8.5 | 26.4 | 15.4 |
| RASGRP1 | 7.3 | 0 | 10.4 | 1.2 | 2.4 | 0 | 0 | 0.1 | 0.2 | 0 | 0 | 27.2 | 7.6 |
| RFXANK | 18.7 | 18.2 | 23.3 | 25.1 | 18.3 | 31.7 | 18.4 | 13.8 | 20.6 | 42.2 | 25.7 | 26.8 | 22.8 |
| RHOH | 1.2 | 0.2 | 54.8 | 41.2 | 12.3 | 4.7 | 0 | 0 | 5.8 | 0.1 | 1.2 | 49.6 | 5.3 |
| SMARCAL1 | 15.2 | 14 | 12.8 | 8.9 | 16.6 | 15.9 | 9.6 | 7.3 | 6.8 | 11 | 9.2 | 12.6 | 14.4 |
| SPINK5 | 48.6 | 0 | 0 | 0 | 0 | 0 | 0 | 12.1 | 0.2 | 0 | 0.2 | 0 | 0 |
| STK4 | 11.4 | 13.3 | 14.5 | 10.8 | 10.3 | 6.9 | 11.6 | 12.4 | 26.7 | 16.9 | 12.8 | 19.9 | 12.9 |
| TPP2 | 14.1 | 6.1 | 12.1 | 6 | 10.9 | 5.8 | 15.9 | 15.7 | 37.6 | 42.2 | 27.2 | 17.3 | 19.2 |
| WAS | 2.2 | 5.3 | 3.2 | 2.1 | 2.1 | 3.5 | 0.2 | 0.7 | 9.6 | 19.2 | 24.4 | 19.4 | 16.9 |
| ZAP70 | 1 | 0.2 | 37.4 | 0.4 | 26.4 | 0.2 | 0 | 0 | 0 | 0 | 0 | 61.5 | 2.4 |
All values were extracted from the Human Protein Atlas (https://www.proteinatlas.org/) (Uhlén et al. 2015). Gene names in bold typeface correspond to genes with intermediate or higher penetrance for HPV susceptibility. The values are the normalized values extracted from the Human Protein Atlas database. DCs: dendritic cells. A431: skin squamous cell carcinoma. Hacat: spontaneously immortalized keratinocytes. HL-60: acute myeloid leukemia. THP-1: promonocytic leukemia. U937: histiocytic lymphoma. MOLT4: acute lymphoblastic leukemia (T). REH: acute lymphocytic leukemia (Non-T; Non-B). Color code: white = 0; red = maximum value. The maximum value of each gene was set independently for the primary and tumor cell lines.