Table 1.
Characteristics of the participants at baseline according to BP-control group
| Total | A Standard (140 ~ < 150 mmHg) |
B Moderate (130 ~ < 140 mmHg) |
C Intensive (< 130 mmHg) |
P value* | |
|---|---|---|---|---|---|
| Number | 105 | 35 | 35 | 35 | |
| Age (years) | |||||
| Overall | 68.4 ± 5.5 | 67.4 ± 4.9 | 68.2 ± 5.8 | 69.5 ± 5.8 | 0.259 |
| ≥ 75 years of age | 17 (16.2%) | 3 (8.6%) | 6 (17%) | 8 (22.9%) | |
| Baseline blood pressure (mmHg) | |||||
| Systolic | 149.6 ± 11.6 | 146.7 ± 8.6 | 147.2 ± 7.0 | 150.6 ± 8.5 | 0.098 |
| Diastolic | 89.2 ± 9.7 | 87.3 ± 9.1 | 88.5 ± 9.5 | 89.7 ± 10.6 | 0.581 |
| BMI | 26.5 ± 3.4 | 25.8 ± 3.3 | 26.9 ± 3.8 | 26.8 ± 3.1 | 0.346 |
| Sex | 1 | ||||
| Male | 33 (31.4%) | 11 (31.4%) | 11 (31.4%) | 11 (31.4%) | |
| Female | 72 (68.6%) | 24 (68.6%) | 24 (68.6%) | 24 (68.6%) | |
| Smoking status | 0.446 | ||||
| Never | 84 (80.0%) | 27 (77.1%) | 27 (77.1%) | 30 (85.7%) | |
| Former | 12 (11.4%) | 6 (17.1%) | 3 (8.6%) | 3 (8.6%) | |
| Current | 9 (8.6%) | 2 (5.7%) | 5 (14.3%) | 2 (5.7%) | |
| Diabetes history | 16 (15.2%) | 6 (17.1%) | 3 (8.6%) | 7 (20.0%) | |
| Distribution of systolic blood pressure (number %) | 0.143 | ||||
| > 150 mmHg | 43 (41.0%) | 11 (31.4%) | 12 (34.3%) | 20 (57.1%) | |
| > 140 ≤ 150 mmHg | 48 (45.7%) | 17 (48.6%) | 19 (54.3%) | 12 (34.3%) | |
| > 130 ≤ 140 mmHg | 14 (13.3%) | 7 (20.0%) | 4 (11.4%) | 3 (8.6%) | |
| Antihypertensive drug use | 1.4 | 1.4 | 1.4 | 1.5 | 0.923 |
| Other medication usage | |||||
| Statins | 6 (5.7%) | 1 (2.9%) | 3 (8.6%) | 2 (5.7%) | |
| Aspirin | 21 (20.0%) | 6 (17.1%) | 7 (20%) | 8 (22.9%) | |
| Laboratory results | |||||
| Glucose (mmol/L) | 6.5 ± 1.7 | 6.7 ± 1.8 | 6.4 ± 2.0 | 6.3 ± 1.3 | 0.559 |
| Cholesterol (mmol/L) | 5.5 ± 1.5 | 5.1 ± 1.8 | 5.6 ± 1.0 | 5.8 ± 1.5 | 0.103 |
| Triglycerides (mmol/L) | 1.8 ± 1.5 | 2.0 ± 2.2 | 1.7 ± 1.1 | 1.8 ± 0.9 | 0.575 |
| LDL (mmol/L) | 4.1 ± 0.9 | 3.9 ± 0.9 | 4.0 ± 0.9 | 4.3 ± 0.9 | 0.307 |
| HDL (mmol/L) | 1.5 ± 0.3 | 1.5 ± 0.3 | 1.5 ± 0.3 | 1.5 ± 0.3 | 0.913 |
| Homocysteine (μmol/L) | 10.4 ± 2.6 | 10.6 ± 3.2 | 9.9 ± 1.9 | 10.5 ± 2.7 | 0.496 |
| MTHHR C677T | 0.679 | ||||
| CC | 24 (22.9%) | 7 (20.0%) | 7 (20.0%) | 10 (28.6%) | |
| CT | 52 (49.5%) | 20 (57.1%) | 18 (51.4%) | 14 (40.0%) | |
| TT | 29 (27.6%) | 8 (22.9%) | 10 (28.6%) | 11 (31.4%) | |
Data are mean (SD) or number (%)
ACE angiotensin-converting enzyme, ARB angiotensin-II-receptor blocker, BMI body mass index, BP blood pressure, MTHFR methylenetetrahydrofolate reductase, LDL low-density lipoprotein, HDL high-density lipoprotein
*Difference between groups p < 0·0001