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. 2020 Jun 11;18:90. doi: 10.1186/s12951-020-00646-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Drug responses of chemosensitivity assay in HO-8910PM cells cultured in gel-cell clumps and common 2D flat cell plates by clinically first-line chemotherapeutic agents (cisplatin and paclitaxel). The precultured cancer cells in three types of hydrogel biomaterials were evaluated by the end point assay for cell survival. ^a(P < 0.01) compared with that of 2D cell culture model. ^b(P < 0.01) compared with that of Matrigel. ^c(P < 0.01) compared with that of RADA16-I hydrogel