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. 2020 Jun 12;20:236. doi: 10.1186/s12935-020-01291-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — SNHG16 is up-regulated and miR-338-3p is down-regulated in cisplatin resistant neuroblastoma tissues and cells. a, b The expression of SNHG16 and miR-338-3p was detected using qRT-PCR in cisplatin resistant and sensitive neuroblastoma tumor tissue. c, d The IC50 value for cisplatin was calculated by CCK-8 assay in SK-N-AS-R and SK-N-SH-R cells. e Western blot analysis of the levels of MRP1 and p-gp protein in cisplatin-resistant neuroblastoma cell lines SK-N-AS-R and SK-N-SH-R and parental SK-N-AS and SK-N-SH was performed. f, g The expression of SNHG16 and miR-338-3p was detected using qRT-PCR in cisplatin-resistant neuroblastoma cell lines (SK-N-AS-R and SK-N-SH-R) and corresponding parental neuroblastoma cell lines (SK-N-AS and SK-N-SH). The same experiment was repeated three times, and the average was taken. *P < 0.05