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. 2020 Jun 5;8:430. doi: 10.3389/fcell.2020.00430

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Copyright © 2020 Guo, Wang, Shi, Ye, Yan, Chen, Zhang, Jin and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conjoint analysis of differentially methylated genes and differentially expressed genes. (A) Distribution of mRNAs with a significant change in both m⁵C modification and gene expression levels in healthy controls (HCs) and SLE stable (SA)/SLE moderate/major active (SM-MA) patients, respectively. (B) Reactome pathways analysis of hypermethylated mRNAs with up-regulated genes in SA versus HC (left) or SM-MA versus HC (right) groups, respectively.