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. 2020 Jun 5;8:430. doi: 10.3389/fcell.2020.00430

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Copyright © 2020 Guo, Wang, Shi, Ye, Yan, Chen, Zhang, Jin and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Down-regulation of NSUN2 is involved in the pathogenesis of systemic lupus erythematosus. (A) NSUN2 mRNA expression level in CD4⁺ T cells from SLE patients (n = 22) and healthy controls (HCs) (n = 23). Data are presented as 2^–Δct relative to GAPDH expression (mean ± standard deviation; **p < 0.01). (B) NSUN2 protein expression levels in CD4⁺ T cells from five SLE patients, five HCs, and two positive control cell lines (Jurkat and HEK293T). The gray scale of WB was measured by ImageQuant software and compared between SLE patients and HCs (*p < 0.05). NSUN2 protein expression was normalized to that of GAPDH. (C) Overlap of differentially hypomethylated genes in siNSUN2-HeLa cells with SLE stable (SA) versus HC and SLE moderate/major active (SM-MA) versus HC hypomethylated mRNAs. (D) Reactome pathways analysis of potential methylated target genes of methylase NSUN2.