Table 2.
Mediation analysis of the relationship between number of child maltreatment and CVD
| Outcome modela | Mediator modelb | Percent mediated | P | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | OR/β (95% CI) | P | |||
| Short sleeper | 1.24 (1.10, 1.41) | 0.0007 | 1.14 (1.11, 1.18) | < 0.0001 | 2.4 | 0.04 |
| Smoker/ex-smoker | 1.13 (1.07, 1.20) | < 0.0001 | 1.20 (1.18, 1.21) | < 0.0001 | 14.7 | 0.02 |
| Obesity | 1.15 (1.08, 1.22) | < 0.0001 | 1.04 (1.03, 1.06) | < 0.0001 | 2.0 | 0.07 |
| TV viewing time | 1.03 (1.00, 1.06) | 0.03 | 0.00 (− 0.01, 0.00) | 0.13 | – | – |
| Systolic blood pressure | 1.12 (1.09, 1.15) | < 0.0001 | − 0.02 (− 0.02, − 0.01) | < 0.0001 | – | – |
| Handgrip strength | 0.96 (0.93, 1.00) | 0.08 | 0.00 (− 0.01, 0.00) | 0.69 | – | – |
| Depressive symptom | 1.18 (1.16, 1.21) | < 0.0001 | 0.22 (0.22, 0.23) | < 0.0001 | 56.2 | < 0.0001 |
| HDL cholesterol | 0.85 (0.82, 0.88) | < 0.0001 | − 0.02 (− 0.02, − 0.01) | < 0.0001 | 8.7 | 0.03 |
| Glycated haemoglobin | 1.10 (1.08, 1.12) | < 0.0001 | 0.00 (0.00, 0.01) | 0.31 | – | – |
| Cystatin C | 1.09 (1.07, 1.11) | < 0.0001 | 0.00 (0.00, 0.01) | 0.10 | – | – |
| Gamma-glutamyltransferase | 1.05 (1.03, 1.07) | < 0.0001 | 0.00 (0.00, 0.01) | 0.28 | – | – |
ORs were presented for short sleeper, smoker/ex-smoker, and obesity
aOutcome model: CVD regressed by potential mediators
bMediator model: potential mediator regressed by child maltreatment