Table 1.
Baseline clinical characteristics in IMN patients with and without DM
| Clinical characteristics | Non-DM (n = 164) |
DM (n = 42) |
P-value |
|---|---|---|---|
| Age (years) | 48 ± 15 | 60 ± 9 | < 0.001 |
| male (n, %) | 94(57.3) | 21 (50.0) | 0.394 |
| SBP (mmHg) | 134 ± 20 | 137 ± 21 | 0.505 |
| DBP (mmHg) | 82 ± 12 | 78 ± 11 | 0.062 |
| Hypertension (n, %) | 71 (43.3) | 17 (40.5) | 0.742 |
| Glomerular hematuria (n, %) | 15 (9.1) | 3 (7.1) | 0.682 |
| eGFR (ml/min/1.73m2) | 91.5 ± 21.9 | 76.1 ± 27.1 | 0.001 |
| Serum creatinine (μmol/L) | 84 ± 45 | 96 ± 55 | 0.134 |
| Proteinuria (g/24 h) | 5.5 ± 3.8 | 7.2 ± 6.0 | 0.084 |
| Albuminuria (g/24 h) | 3.1 ± 2.1 | 3.4 ± 2.4 | 0.522 |
| uPCR (mg/gCr) | 4.4 ± 3.6 | 5.9 ± 4.9 | 0.074 |
| uACR (mg/gCr) | 2.4 ± 1.9 | 2.8 ± 2.2 | 0.173 |
| Serum albumin (g/L) | 22.4 ± 7.4 | 22.4 ± 5.7 | 0.943 |
| Hemoglobin (g/L) | 129.3 ± 20.2 | 120.3 ± 21.6 | 0.012 |
| Blood uric acid (μmol/L) | 427.2 ± 120.5 | 402.8 ± 103.8 | 0.232 |
| Cholesterol (mmol/L) | 8.7 ± 3.0 | 8.2 ± 2.5 | 0.349 |
| Triglyceride (mmol/L) | 3.1 ± 2.2 | 3.3 ± 2.1 | 0.588 |
| HDL (mmol/L) | 1.5 ± 0.5 | 1.5 ± 0.5 | 0.652 |
| LDL (mmol/L) | 5.5 ± 2.0 | 5.1 ± 1.7 | 0.233 |
| Glycosylated hemoglobin (%) | 5.6 ± 0.5 | 6.5 ± 1.0 | < 0.001 |
| Type of Diabetes (n, %) | |||
| Type 1 Diabetes | – | 1 (2.4) | – |
| Type 2 Diabetes | – | 31 (97.6) | – |
| Steroid diabetes | – | 10 (23.8) | |
| Duration of diabetes (n, %) | |||
| New-onset diabetes | – | 27 (64.3) | – |
| Previous diabetes | – | 15 (35.7) | – |
| Therapeutic regimen for DM (n, %) | |||
| Oral hypoglycemic drugs | – | 27 (64.3) | – |
| Insulin | – | 1 (2.4) | – |
| Lifestyle management | – | 14 (33.3) | – |
Data were expressed as mean ± SD (standard deviation), medians (interquartile range), or numbers (%)
DM diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, uPCR urine protein creatinine ratio, uACR urine albumin creatinine ratio, HDL high density lipoprotein, LDL low density lipoprotein