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. 2020 Jun 11;20:546. doi: 10.1186/s12885-020-07018-6

Table 1.

Attributes and levels used for the DCE

Attribute Level used in design Level used in modelb
Average overall survivala & Remission period 1 year survival 3 months remission 1 Short
9 months remission 1 Long
3 years survival 9 months remission 3 Short
2 years 3 months remission 3 Long
5 years survival 1 year 3 months remission 5 Short
3 years 9 months remission 5 Long
7 years survival 1 year 9 months remission 7 Short
5 years 3 months remission 7 Long
9 years survival 2 years 3 months remission 9 Short
6 years 9 months remission 9 Long
Side effects Mild or moderate None 0
20% risk, lasting up to 2 months 20
20% risk, lasting longer than 2 months 20
40% risk, lasting up to 2 months 40
40% risk, lasting longer than 2 months 40
60% risk, lasting up to 2 months 60
60% risk, lasting longer than 2 months 60
Severe None None
5% risk, lasting up to 2 months Some
5% risk, lasting longer than 2 months Some
10% risk, lasting up to 2 months Some
10% risk, lasting longer than 2 months Some
Mode & Frequency of administration Oral Daily Oral
Weekly Oral
Subcutaneous (SC) 2–3 times per week SC - high
Weekly SC - high
Fortnightly SC - low
Monthly SC - low
Intravenous (IV) 2–3 times per week IV - high
Weekly IV - high
Fortnightly IV – low
Monthly IV - low
Annual out of pocket costsc $0 0
$500 5
$1500 15
$3000 30
$5000 50

aAverage overall survival was treated as a quantitative variable in the model

bincludes regrouping of levels for certain attributes

cDivided by 100 for modelling purposes