TABLE 2.
Results of multiple logistic and linear regression analyses for assessing the relationship between serum UA and Aβ, AV-1451, AD-CM, or WMH volume in non-demented older adults.
| OR | 95% CI | P | |
| Aβ positivity | |||
| Model 1 | 1.009 | 0.848 to 1.200 | 0.920 |
| Model 2 | 1.010 | 0.838 to 1.217 | 0.916 |
| Model 3 | 1.068 | 0.854 to 1.336 | 0.565 |
| B | 95% CI | P | |
| Aβ retention, SUVR | |||
| Model 1 | –0.002 | −0.019 to 0.015 | 0.812 |
| Model 2 | 0.001 | −0.017 to 0.018 | 0.950 |
| Model 3 | 0.001 | −0.015 to 0.017 | 0.877 |
| AV-1451, SUVR | |||
| Model 1 | –0.062 | −0.189 to 0.065 | 0.334 |
| Model 2 | –0.070 | −0.203 to 0.062 | 0.296 |
| Model 3 | –0.052 | −0.168 to 0.064 | 0.377 |
| AD-CM, SUVR | |||
| Model 1 | 0.010 | <0.001 to 0.020 | 0.043 |
| Model 2 | 0.011 | <0.001 to 0.021 | 0.042 |
| Model 3 | 0.014 | 0.004 to 0.024 | 0.006 |
| WMH, cm3 | |||
| Model 1 | 0.067 | −0.354 to 0.489 | 0.754 |
| Model 2 | –0.031 | −0.463 to 0.402 | 0.889 |
| Model 3 | –0.039 | −0.488 to 0.410 | 0.865 |
Abbreviations: UA, uric acid; Aβ, beta-amyloid; AD-CM, Alzheimer’s disease signature cerebral glucose metabolism; WMH, white matter hyperintensities; CI, confidence interval. The results of multivariate logistic or linear regression analyses are presented with OR B coefficient values, 95% CI and P-value. Global Aβ retention was used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates, model 2 included age and sex as covariates, and model 3 included all potential covariates, including age, sex, education, apolipoprotein ε4, vascular risk score, clinical diagnosis, serum albumin, body mass index, smoking status, and alcohol intake status.