TABLE 7.

Results of general linear model analyses for assessing the relationship between serum UA strata and cognitive performance in non-demented older adults.

	Type III SS	df	MS	F	P
WLR z-Score	9.846	2	4.923	3.602	0.028
WLR z-Scorea	4.675	2	2.338	1.822	0.163
MMSE z-Score	8.349	2	4.174	2.751	0.065
MMSE z-Scorea	3.987	2	1.994	1.373	0.255

Abbreviations: UA, uric acid; Aβ, beta-amyloid; AD-CM, Alzheimer’s disease signature cerebral glucose metabolism; WMH, white matter hyperintensities; SS, square sum; MS, mean square; WLR, Word List Recall; MMSE, Mini-Mental State Examination. Global Aβ retention was used after natural log-transformation to achieve normal distribution. ^aTo examine whether the association between UA and cognitive score is mediated by specific brain pathology, we included AD-CM which showed a significant relationship with serum UA as an additional covariate in the model for the association between UA vs. cognitive score.