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PK parameters (Mean ± SD) of Echinomycin in mouse plasma after administration of 0.1 mg of three formulation of Echinomycin
| T1/2 (hr) | Cmax (ng/mL) | AUClast (hr*ng/mL) | |
|---|---|---|---|
| Free-EM | 2.46 ± 0.29 | 0.67 ± 0.24 | 1.78 ± 0.55 |
| CrEL-EM | 4.68 ± 0.65 (P=0.0057)a) | 2.27 ± 0.11 (P=0.00047) | 7.58 ± 0.45 (P=0.00015) |
| Lipo-EM | 4.28 ± 0.61 (P=0.0095) | 8.85 ± 0.88 (P=0.0001) | 24.17 ± 2.58 (P=0.00012) |
P value to Free-EM.
