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. 2020 Jun 5;8:476. doi: 10.3389/fchem.2020.00476

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Copyright © 2020 Dong, Hu, Yu, Tan, Ma, Xi, Li, Wang, Zhou, Chen, Du and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The antimicrobial activity of Dermaseptin-PP against the growth of E. coli, S. aureus, C. albicans, P. aeruginosa, E. faecalis, K. pneumoniae, and MRSA. The data represents means ± SEM (standard error of the mean) of three independent experiments. MHB is blank control; 1% DMSO is vehicle control; Growth represents the growth control (normally growing microorganism in MHB). The Y-axis represents absorbance, higher absorbance refers to more visible microorganisms, indicating lower antimicrobial activity. (B) The hemolytic activity of Dermaseptin-PP (at concentration from 0.5 to 64 μM) on horse erythrocytes. Values are the mean ± SEM for three independent experiments. The significance of group difference was determined by Dunnett's multiple comparisons of one-way ANOVA in GraphPad Prism (version 6.0) software. ****P < 0.0001 vs. positive control (2% Triton X-100).