Table 1.
Cytotoxicity of SC21 and SC23 in the NCI 60 Human Cancer Cell Lines
| Cell Line | SC21 | SC23 | ||
|---|---|---|---|---|
| Experiment 1 GI50 |
Experiment 2 GI50 |
Experiment 1 GI50 |
Experiment 2 GI50 |
|
| Leukemia | ||||
| CCRF-CEM | 1.00E-08 | 1.00E-08 | 1.03E-07 | 5.10E-07 |
| HL-60(TB) | 1.00E-08 | 4.95E-08 | 1.79E-07 | |
| K-562 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 3.32E-07 |
| MOLT-4 | 1.00E-08 | 1.00E-08 | 1.35E-07 | 6.17E-07 |
| RPMI-8226 | 1.00E-08 | 1.00E-08 | 1.28E-07 | 6.17E-07 |
| SR | 4.01E-08 | 4.55E-08 | ||
| Non-Small Cell Lung Cancer | ||||
| A549/ATCC | 1.00E-08 | 1.00E-08 | 1.00E-08 | 1.85E-05 |
| EKVX | 1.00E-08 | 2.25E-06 | 1.48E-06 | 8.36E-07 |
| HOP-62 | 1.00E-08 | 1.00E-08 | ||
| HOP-92 | 1.00E-08 | 1.00E-08 | 3.45E-08 | |
| NCI-H226 | 2.10E-05 | 1.00E-08 | 3.15E-08 | |
| NCI-H23 | 1.00E-08 | 1.00E-08 | 2.33E-07 | |
| NCI-H322M | 1.73E-07 | 4.52E-08 | 1.00E-04 | 2.60E-06 |
| NCI-H460 | 1.00E-08 | 1.00E-08 | 1.83E-07 | |
| NCI-H522 | 1.00E-08 | 2.75E-07 | 3.52E-07 | |
| Colon Cancer | ||||
| COLO205 | 3.03E-06 | 4.21E-06 | 1.00E-04 | 1.00E-04 |
| HCC-2998 | 2.14E-06 | 1.00E-08 | 1.00E-04 | 2.41E-05 |
| HCT-116 | 1.00E-08 | 1.00E-08 | 2.12E-07 | 2.97E-07 |
| HCT-15 | 1.00E-08 | 1.00E-08 | 1.49E-07 | 6.04E-07 |
| HT29 | 1.73E-06 | 3.32E-06 | 1.00E-08 | 1.11E-07 |
| KM12 | 1.38E-05 | 7.03E-07 | 8.37E-07 | |
| SW-620 | 1.00E-08 | 1.52E-08 | 2.28E-07 | 2.13E-06 |
| CNS Cancer | ||||
| SF-268 | 1.00E-08 | 1.00E-08 | 2.32E-08 | |
| SF-295 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 6.97E-08 |
| SF-539 | 1.00E-08 | 1.00E-08 | 2.21E-07 | |
| SNB-19 | 1.00E-08 | 5.23E-08 | ||
| SNB-75 | 1.00E-08 | 3.45E-08 | ||
| U251 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 2.73E-06 |
| Melanoma | ||||
| LOX IMVI | 1.00E-08 | 1.00E-08 | 8.31E-08 | |
| MALME-3M | 4.02E-08 | 1.00E-08 | 1.29E-07 | |
| M14 | 2.70E-08 | 1.00E-08 | 1.00E-08 | 7.39E-08 |
| SK-MEL-2 | 1.00E-08 | 1.41E-07 | ||
| SK-MEL-28 | 5.94E-06 | 2.47E-06 | 4.14E-06 | 1.00E-04 |
| SK-MEL-5 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 4.99E-08 |
| UACC-257 | 6.65E-08 | 4.30E-07 | ||
| UACC-62 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 4.17E-08 |
| Ovarian Cancer | ||||
| IGROV1 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 5.03E-08 |
| OVCAR-3 | 1.22E-07 | 1.50E-08 | 3.25E-07 | |
| OVCAR-4 | 1.00E-08 | 1.40E-06 | 3.85E-07 | 1.22E-06 |
| OVCAR-5 | 2.06E-06 | 1.00E-04 | 1.00E-04 | 1.00E-04 |
| OVCAR-8 | 1.00E-08 | 1.71E-08 | 2.33E-07 | |
| SK-OV-3 | 1.00E-08 | 1.00E-08 | ||
| Renal Cancer | ||||
| 786-0 | 1.00E-08 | 1.00E-08 | 1.98E-07 | |
| A498 | 1.00E-08 | |||
| ACHN | 1.00E-08 | 1.00E-08 | 1.00E-08 | 2.61E-08 |
| CAKI-1 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 5.01E-08 |
| RXF 393 | 1.00E-08 | 1.00E-08 | 1.00E-04 | |
| SN12C | 1.00E-08 | 1.00E-08 | 1.00E-04 | |
| TK-10 | 1.00E-08 | 1.00E-08 | 2.18E-05 | 2.97E-07 |
| UO-31 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 1.28E-08 |
| Prostate Cancer | ||||
| PC-3 | 6.25E-08 | 3.47E-06 | 2.14E-05 | |
| DU-145 | 1.00E-08 | 1.00E-08 | 1.00E-04 | 1.00E-04 |
| Breast Cancer | ||||
| MCF7 | 1.32E-08 | 1.00E-08 | 2.37E-07 | 4.94E-07 |
| NCI/ADR-RES | 1.00E-08 | 1.00E-08 | 7.42E-08 | |
| MDA-MB-231/ATCC | 1.00E-08 | 1.00E-08 | ||
| MDA-MB-435 | 1.00E-08 | 1.00E-08 | 1.00E-08 | 3.24E-08 |
| MDA-N | 1.00E-08 | 1.00E-08 | ||
| T-47D | 1.00E-08 | 1.00E-08 | 1.00E-04 | 1.00E-04 |
| BT-549 | 1.00E-08 | 1.00E-04 | ||
| HS 578T | 1.00E-08 | |||